According to the biennial count rule, how must C-II substances be counted?

In accordance with the biennial inventory guidelines for controlled substances, specifically C-II substances, they must be counted exactly. This requirement ensures accurate tracking of these highly regulated drugs which are prone to misuse and diversion. The exact count provides a precise record of the quantity on hand, which is vital for compliance with legal standards and for auditing purposes.

C-II substances have the highest potential for abuse and dependency, which necessitates stringent regulatory controls. An exact count helps to maintain accountability and ensures that any discrepancies can be identified and addressed promptly.

Other counting methods, such as estimation or visual assessment, do not provide the level of accuracy required for C-II substances, as these methods may lead to inaccuracies that could compromise safety and compliance. Random sample counts would not be suitable because they do not account for the total amount of C-II substances, which is crucial when dealing with medications that are strictly regulated.